[SOLVED] CS

output:
word_document:
toc: yes
title: Pharmacometrics CHLD0085: Answer template
author:
WRITE YOUR candidate number

`{r setup, include=FALSE}
knitr::opts_chunk$set(echo = TRUE)

`

# Write a sentence about each of the 4 PK processes (ADME) from your reading about aminoglycoside PK (4 marks)

WRITE ANSWER HERE

# Read in the data and make a plot of the data, with lines connecting data from each individual, appropriate axis lables and using a log scale for the y-axis (4 marks)

`{r}

# WRITE CODE TO GENERATE ANSWER HERE

`

# Undertake a noncompartmental analysis of the data, reporting the median, 2.5th, and 97.5th percentiles of $C_{max}$, Elimination half-life, $AUC_{(0-t)}$, $AUC_{(0-infty)}$ (4 marks)

`{r}

# WRITE CODE TO GENERATE ANSWER HERE

`

# Using nlmixr() fit 1 and 2 compartment models and test additive or proportional residual errors.Use the Objective Function Value, plots of NPDE *versus* TIME and |IWRES| *versus* IPRED to choose your preferred structural and statistical model.Make a VPC of your final model, and create a table of parameter estimates (8 marks)

`{r}

# WRITE CODE TO GENERATE ANSWER HERE